Egyptian justice minister resigns

CAIRO (Reuters) - Egypt's Justice Minister Ahmed Mekky has resigned in protest at what he sees as "an assault" on the judiciary by the Islamist-led authorities, the Justice Ministry spokesman said on Sunday.

Mekky submitted his resignation to President Mohamed Mursi on Saturday, said the spokesman, Ahmed Salam. It followed a protest on Friday by Mursi's Islamist backers demanding the "purification" of the judiciary.

A bill has been submitted to parliament which critics say would give the government too much control over the make-up of the judiciary.

Mekky, who was appointed in August, had been quoted in local media as saying he would resign if the law was passed. The Islamist-dominated upper house of parliament has yet to vote on the legislation.

Mursi said on Saturday he planned to reshuffle the cabinet.

Mekky was widely regarded as a supporter of judicial independence during the rule of former President Hosni Mubarak, but his critics had accused him of siding with the new Islamist-led authorities.

Thousands of Islamist supporters of Mursi rallied on Friday, calling for an independent judiciary by passing the new legislation and removing corrupt members of legal institutions.

Friction between the government and the judiciary has been on the rise since March when the Administrative Court ordered the cancellation of a Mursi decree calling for parliamentary elections, forcing a delay in voting due to have begun in April.

(Writing by Tom Perry and Asma Alsharif; Editing by Janet Lawrence)

Source: http://news.yahoo.com/egyptian-justice-minister-resigns-124514046.html

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Genetics defines a distinct liver disease

Apr. 21, 2013 ? Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases.

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

Approximately 70 per cent of people who suffer from PSC also suffer from IBD. The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD). For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease.

PSC is a chronic, progressive disease of the bile ducts that channels bile from the liver into the intestines. It can cause inflammation of the bile ducts (cholangitis) and liver scarring that leads to liver cirrhosis and liver failure. There are no effective treatments available. Although PSC affects only one in 10,000 people, it is a leading cause of liver transplant surgery.

?Before our study, it was never quite clear whether PSC was a complication of IBD or a distinct disease in its own right,? says Dr Carl Anderson, lead author from the Wellcome Trust Sanger Institute. ?We have proven it to be a unique disease, and hope that our results will inform the development of more effective treatments, designed to target the biological pathways involved in causing the disease?.

The work involved an international group of scientists from the International PSC study group recruiting patients from 13 countries within Europe and North America. Without this large collaborative effort it would not have been possible to obtain the large number of patient DNA samples necessary for the study.

The team used DNA genotyping technology to survey more thoroughly regions of the genome known to underlie other immune-related diseases to discover if they also play a role in PSC susceptibility.

In addition to the nine genetic regions newly associated, they also saw strong signals at three regions of the genome previously associated with the disease. Of these twelve genetic regions, six are also associated with IBD, while the six other regions showed little to no association in a recent large study of IBD.

?Using the Immunochip genotyping chip, we can pull apart the genetic relationships between these autoimmune diseases and begin to see not only their genetic similarities, but also the differences,? says Jimmy Liu, PhD student and first author from the Wellcome Trust Sanger Institute. ?As PSC is a rare disorder, sample collection is more difficult than for other, more common, autoimmune diseases. We hope that with more samples from patients, we?ll be able to link more genetic regions to the disease, and it will become easier to identify underlying pathways that could act as therapeutic targets.?

Three of the genetic regions associated with PSC fall within a single biological system that underlies variation in T cells, cells important to our immune response. One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.

In an extended analysis, the team identified an additional 33 genetic regions that are also involved in several common immune-mediated conditions (celiac disease, Crohn?s disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, sarcoidosis and psoriasis). This analysis shows that PSC shares many genetic risk loci with other immune-mediated diseases and opens up the possibility for testing drugs known to be effective in genetically similar diseases for efficacy in PSC.

The next step for the team is to do a high-powered search throughout the entire genomes of PSC patients to find specific regions associated with PSC outside of the regions included on the Immunochip genotyping chip.

?This study has uncovered more about the genetics underlying PSC than any before it, but this is only the first step? says Dr Tom Hemming Karlsen, lead author from Oslo University Hospital, Norway. ?We hope the ongoing scientific and clinical research being conducted through the International PSC study group will help improve the outlook for those currently suffering at the hands of this disease?

?Our study, which is the largest of its type for PSC, would not have been possible without the help of the patients with this rare disorder,? adds Dr Hemming Karlsen.

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The above story is reprinted from materials provided by Wellcome Trust Sanger Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Jimmy Z Liu, Johannes Roksund Hov, Trine Folseraas, Eva Ellinghaus, Simon M Rushbrook, Nadezhda T Doncheva, Ole A Andreassen, Rinse K Weersma, Tobias J Weism?ller, Bertus Eksteen, Pietro Invernizzi, Gideon M Hirschfield, Daniel Nils Gotthardt, Albert Pares, David Ellinghaus, Tejas Shah, Brian D Juran, Piotr Milkiewicz, Christian Rust, Christoph Schramm, Tobias M?ller, Brijesh Srivastava, Georgios Dalekos, Markus M N?then, Stefan Herms, Juliane Winkelmann, Mitja Mitrovic, Felix Braun, Cyriel Y Ponsioen, Peter J P Croucher, Martina Sterneck, Andreas Teufel, Andrew L Mason, Janna Saarela, Virpi Leppa, Ruslan Dorfman, Domenico Alvaro, Annarosa Floreani, Suna Onengut-Gumuscu, Stephen S Rich, Wesley K Thompson, Andrew J Schork, Sigrid N?ss, Ingo Thomsen, Gabriele Mayr, Inke R K?nig, Kristian Hveem, Isabelle Cleynen, Javier Gutierrez-Achury, Isis Rica?o-Ponce, David van Heel, Einar Bj?rnsson, Richard N Sandford, Peter R Durie, Espen Melum, Morten H Vatn, Mark S Silverberg, Richard H Duerr, Leonid Padyukov, Stephan Brand, Miquel Sans, Vito Annese, Jean-Paul Achkar, Kirsten Muri Boberg, Hanns-Ulrich Marschall, Olivier Chazouill?res, Christopher L Bowlus, Cisca Wijmenga, Erik Schrumpf, Severine Vermeire, Mario Albrecht, John D Rioux, Graeme Alexander, Annika Bergquist, Judy Cho, Stefan Schreiber, Michael P Manns, Martti F?rkkil?, Anders M Dale, Roger W Chapman, Konstantinos N Lazaridis, Andre Franke, Carl A Anderson, Tom H Karlsen. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nature Genetics, 2013; DOI: 10.1038/ng.2616

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Eq8ub1bLGf0/130421152410.htm

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1st Year Analysts: Take Home After Taxes | Wall Street Oasis

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Scroll Marker Helps Keep Your Place on Long Web Pages

Chrome: If you're reading a long article on a computer screen, it can be easy to lose your place while scrolling. Scroll Marker draws a small line at the bottom of your screen to keep your eyes in the right place while you move down the page.

This is basically the digital equivalent of using a bookmark or your finger to keep track of your position on a printed page. When you enable the extension, it will draw a thin line across the bottom of your browser. When you scroll, it will move with the content and remain in place for a few moments to keep you from losing your spot. For such a simple app, Scroll Marker comes with lots of customization options. You can change the size and color of the line, how far it's offset from the bottom of the browser window, and how long it stays in place after you scroll.

This is something you'll probably keep disabled most of the time, but it's helpful if you're on a page without much formatting that doesn't give you a lot of visual anchors, or if you're the kind of person that has to keep a finger on the page.

Scroll Marker (Free) | Chrome Web Store via AddictiveTips

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/glbmr4UvO3g/scroll-marker-helps-keep-your-place-on-long-web-pages-476390294

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Twitter launches iTunes-connected #music app for iOS

This morning Twitter announced #music, a new app which allows Twitter users to post and listen to embedded tracks from iTunes, Spotify, or Rdio. By checking out the new #NowPlaying section, you can get a snapshot view of what's being listened to by the people you follow. For those looking for something new, you can flip through the Suggested, Emerging, and Popular sections. If you're a subscriber to either Spotify or Rdio, you can listen to the full tracks, but otherwise you just get an iTunes preview. Links are provided to the Twitter accounts of performing artists from the playback window, along with options to share the track yourself.

What's particularly interesting about this whole thing is that #music isn't just folded into the native Twitter app; it's an entirely separate app altogether. It's certainly cool that Twitter's making new apps, but I can't help but feel that this feature could have been a huge differentiator to the native Twitter client. It also feels like the iTunes connection could be a bit stronger than simply pulling in previews and linking off to the store; Twitter was cozy with Ping once upon a time, after all.

The initial rollout for Twitter #music is taking place in the U.S., Canada, UK, Ireland, Australia, and New Zealand. An Android roll-out and wider international spread are in the works, but in the meantime, they can still enjoy the web version. Spotify and Rdio customers, are you pumped about the new service? Those of you that aren't subscribers, could a social engine like this get you to sign up? Could you see yourself buying a track through iTunes that was discovered through Twitter #music?

• Free - Download Now

Source: Twitter

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/QGejKEH0YFU/story01.htm

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Venezuela crackdown called worst in years

CARACAS, Venezuela (AP) ? National Guard troops beat dozens of opposition supporters inside a barracks for refusing to accept the government-certified electoral victory of Hugo Chavez's heir, a leading human rights lawyer charged Thursday in what he called Venezuela's worst political repression in six years.

Alfredo Romero said his group's lawyers also compiled evidence supporting opposition activists' claims that National Guard troops had used excessive force against protesters, including shooting some point-blank with plastic shotgun pellets.

As details of the crackdown emerged, Nicolas Maduro prepared to be sworn in as president and the speaker of the National Assembly again threatened to bar the opposition from its only remaining political platform, the legislature, unless it recognized Maduro's legitimacy.

Romero said the beatings occurred at National Guard barracks No. 47 in the western city of Barquisimeto after at least 300 protesters were arrested across Venezuela for backing opposition candidate Henrique Capriles' demand for a recount of all the votes cast Sunday.

Interrogators "put baseball caps on these kids' heads with a pro-government insignia ... and made them say they recognized the Maduro government, and if they said 'No' they were beaten," Romero said, adding that most of the detainees ranged in age from 15 to 22.

Asked about the allegations, Interior Ministry spokesman Jorge Galindo called them "totally false, absurd and without basis." He said the detainees, though in a military barracks, were being overseen by ministry officials to "guarantee their rights."

Romero called the crackdown Venezuela's worst since Chavez shut down the opposition TV station RCTV in 2006 when more than 250 people were arrested. His 12-year-old group, Foro Penal Venezolano, has more than 200 lawyers who represent without charge people they consider political prisoners.

He said the group has complained to the Inter-American Human Rights Commission, whose rulings Venezuela's government no longer recognizes, and is preparing a complaint to the International Criminal Court.

One of the worst cases of excessive force this week occurred in the central city of Valencia, members of the opposition's youth wing said in Caracas.

They said National Guardsmen fired plastic pellets at extremely close range at a group protesting the regime-friendly National Electoral Council's decision to ratify the victory of Nicolas Maduro.

Maduro is to be sworn in Friday in the National Assembly at a ceremony being boycotted by the opposition because its deputies are not being allowed to address the body unless they recognize his presidency as legitimate.

The government says 15 countries including Iran, China and Saudi Arabia were sending high-level delegations. Brazil said its president, Dilma Rousseff, was attending as was Argentina's Cristina Fernandez, but it was not clear whether the president of neighboring Colombia, Juan Manuel Santos, would attend.

On Thursday, Maduro headed to Lima, Peru, for an evening meeting of presidents of the Union of South American Nations, UNASUR, to discuss Venezuela's post-election tensions.

The meeting was convened by Peru's president, Ollanta Humala, who holds the organization's rotating chair, and every leader on the continent save Ecuador's Rafael Correa, who was traveling in Europe, was attending, said Peru's deputy foreign minister, Fernando Rojas.

The youth opposition wing members displayed photographs showing deep, bloody wounds on the skin the hand and arm of Jonny Alvarado, a local leader of the centrist Proyecto Venezuela party who they said had been shot three times in the arm and undergone two surgeries in an attempt to save his hand.

The AP confirmed Alvarado's non-life-threatening injuries with the director of the hospital where he was treated.

At least 10 other activists were hit by pellets, some in the head, but not hurt as seriously, said Carlos Graffe, Proyecto Venezuela's youth leader. He said other protesters were punched or hit with batons by National Guardsmen.

A total of 400 were injured nationwide by authorities and government backers, said Juan Requesens, national coordinator of the opposition's youth wing.

In Monagas state, a group of 30 to 40 protesters was attacked by pro-government forces, then detained by authorities when they tried to flee, said Diego Scharifker, president of the youth wing of the Nuevo Tiempo party. He said virtually all were anti-government, but National Guard members had even swept up a handful of pro-government youth during sweeps of streets.

Romero said other activists described being arrested as they were walking home from peaceful protests.

The government alleges Capriles' backers have incited all the postelection violence, which it says has caused eight deaths and 70 injuries. It also charges the opposition loyalists have burned eight health clinics and several offices of the ruling United Socialist Party of Venezuela.

Non-government media and private citizens have published photos of unmolested clinics and party offices that they said disproved the claims.

Chief Prosecutor Luisa Ortega reiterated on Thursday the government's contention that neither it nor its supporters were to blame for any of the violence that followed Sunday's vote.

"A common denominator is that the wounded and injured are all supporters of Chavismo," she said in an interview on state TV.

Romero said 71 youths in all were arrested in Barquisimeto on Monday and Tuesday, when opposition supporters marched on regional offices of the electoral council, while 83 were arrested in Valencia over those two days.

He said it appeared that most were being freed Thursday, but that many faced criminal charges that include public incitement, destroying public property and other crimes.

Other arrests occurred in the states of Barinas, Merida and Maracay, Romero added, but he said he didn't have solid information on events there.

The prosecutor, Ortega, said Thursday that a total of 135 people had been arrested across Venezuela, with 90 of them charged with crimes.

The country awaited, meanwhile, word on whether the electoral council would agree to Capriles demand for a vote-by-vote recount after receiving the opposition's petition on Wednesday.

National Assembly Speaker Diosdado Cabello repeated the threat he made Tuesday to bar the opposition from the chamber, it's only platform on the national political stage. The opposition has just three of Venezuela's 23 governorships.

"I repeat to deputies of the opposition, just in case by chance they didn't understand, if they don't recognize Maduro as president I won't recognize them in the AN (National Assembly)."

There would be no constitutional basis for such an action, but Maduro and his ruling circle has paid little heed to the document since their mentor disappeared in December to Cuba for cancer surgery, never to be heard from publicly again.

Cabello was one of the closest allies of Chavez, who died March 5 after a long battle with cancer.

The ruling socialists control the legislature with 165 seats to 98 for the opposition and elections are not due until next year.

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Associated Press writers E. Eduardo Castillo and Vivian Sequera contributed to this report.

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Frank Bajak on Twitter: http://twitter.com/fbajak

Michael Weissenstein on Twitter: http://twitter/mweissenstein

Source: http://news.yahoo.com/venezuela-crackdown-deemed-worst-years-230149996.html

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